Cross-section schematic: SPR laser from below, microscope objective above, through the open-aperture fluidic head

Ipso-Lux ©  ·  Open fluidic head

SPR and microscopy,
in the same experiment

Position a microscope objective directly above the gold surface and combine binding kinetics with fluorescence, brightfield, or photoactivation, in real time.

Ipso-LAB instrument SPR + microscopy applications

Open fluidic head

A unique open access
to your SPR cell

  • An open fluidic head allows approaching a microscope objective directly to the SPR cell.
  • Visualize what's happening inside the 100 µm transparent microfluidic channel, in parallel with the live SPR sensorgram.
  • Observe the reaction through a 1 mm glass ceiling in the 2 independent fluidic channels.
Ipso-LAB open-aperture fluidic head with vertical access for a microscope objective

Open-aperture fluidic head — 2 independent channels

Ipso-LAB in a university lab
Ipso-Lux©

Ipso-LAB© with an open fluidic head.

Ipso-Lux = Ipso-LAB + open fluidic head

A glass-top flow cell opens optical access above the SPR chip — illuminate, excite, or image your sample while SPR kinetics run continuously at the gold surface.

Ipso-LAB full specifications

Research applications

Ipso-Lux opens SPR
to light-driven science

Photoswitchable binding kinetics

Illuminate the sample during the SPR run and watch kon and koff respond as your molecule toggles between isomers — azobenzenes, diarylethenes, or any photoswitch. Both binding states captured in a single run, under controlled illumination.

Optogenetic protein interactions

Activate a LOV domain, cryptochrome, or phytochrome on the sensor chip with a light pulse and immediately record the change in binding kinetics. One measurement bridges structural biophysics and light-driven cellular function.

Fluorescence & TIRF imaging

Place a microscope objective above the chip and capture TIRF or brightfield images while the SPR sensorgram runs. Spatially resolved molecular events and ensemble binding kinetics — simultaneous, on the same sample.

An experiment in mind
with Ipso-Lux?

Share your measurement challenge and our scientists will assess how Ipso-Lux fits your workflow.

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